RecruitingNot ApplicableNCT07033572

Hybrid Endoscopic Hemithyroidectomy and Targeted Ablation for Bilateral Papillary Thyroid Carcinoma


Sponsor

Fujian Medical University

Enrollment

60 participants

Start Date

Jun 1, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This study evaluates a thyroid-function-preserving alternative to routine total thyroidectomy for bilateral papillary thyroid carcinoma (PTC). Eligible adults undergo remote-access gas-less axillo-breast endoscopic hemithyroidectomy with level VI dissection on the dominant side, followed by ultrasound-guided radiofrequency ablation (RFA) of a ≤7 mm contralateral focus during the same anesthesia. Outcomes include structural-recurrence-free survival, endocrine-function preservation, safety, and quality of life over 24 months.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new surgical approach for people with papillary thyroid cancer (a common, slow-growing thyroid cancer) that has spread to both sides of the thyroid — removing one side surgically and treating the other side with a non-surgical heat-based ablation technique, all in one procedure. **You may be eligible if...** - You are between 18 and 65 years old - Your main thyroid tumour is 1.5 cm or smaller and suitable for endoscopic (minimally invasive) surgery - The tumour on the other side of your thyroid is 7 mm or smaller and in a safe location - There is no sign of cancer spread to nearby lymph nodes on the smaller-tumour side - You provide written consent **You may NOT be eligible if...** - Your cancer has spread beyond the thyroid or to distant parts of the body - You have had previous neck surgery, prior ablation treatments, or neck radiation - You are pregnant or breastfeeding - You have serious other health conditions that make surgery or anesthesia unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopic Hemithyroidectomy with Central-Neck Dissection

Gas-less axillo-breast approach (trans-axillary + peri-areolar), carbon-dioxide-free working space, removing dominant thyroid lobe plus level VI lymph nodes; intra-operative neuromonitoring used throughout.

PROCEDUREUltrasound-Guided Radiofrequency Ablation of Contralateral Nodule

17-gauge internally-cooled electrode, 0.7 cm active tip, power 40 W; moving-shot technique under real-time ultrasound until hyperechoic halo fully covers ≤ 7 mm papillary microcarcinoma ≥ 2 mm from posterior capsule; same anesthesia session as surgery.


Locations(1)

Fujian Medical University Union Hospital

Fuzhou, Fujian, China

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NCT07033572


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