RecruitingNot ApplicableNCT07034599

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.


Sponsor

Karlsburg Hospital

Enrollment

30 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

All patients undergoing an implantation of a durable left ventricular assist device and monitored by pulmonary artery catheter showing no adverse events after surgery are included in the study and ventilated for 15 minutes using extra thoracic negative pressure ventilation and usual intrathoracic positive pressure ventilation. Hemodynamics changes between both ventilation modes, especially focussing on right ventricular function and measured by a pulmonary artery catheter, are compared.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a non-invasive breathing support device called a cuirass ventilator (a shell that fits over the chest) can help the heart and right ventricle function better after a patient receives a left ventricular assist device (LVAD) — a mechanical pump implanted to help a failing heart pump blood. **You may be eligible if...** - You have recently had a durable left ventricular assist device (LVAD) implanted **You may NOT be eligible if...** - You had complications during your LVAD surgery (such as major bleeding or emergency complications) - The cuirass breathing device doesn't physically fit you - A study investigator is unavailable - Your circulation or breathing is currently unstable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICENegative pressure ventilation

All participants are ventilated with negative pressure ventilation first

DEVICEpositive pressure ventilation

All participants are ventilated using positive pressure ventilation after negative pressure ventilation


Locations(1)

Klinikum Karlsburg

Karlsburg, Germany

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NCT07034599


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