RecruitingNCT07035743
Bronchial Response to Exercise After Double Lung Transplantation
Sponsor
Chang Gung Memorial Hospital
Enrollment
40 participants
Start Date
Jun 5, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
This study aims to investigate the airway response to exercise and its association with breathlessness in double lung transplant recipients by comparing responses during 5-minute and 15-minute exercise durations.
Eligibility
Min Age: 20 Years
Inclusion Criteria2
- Received double lung transplantation
- ≥ 3 months post-transplant
Exclusion Criteria5
- Diagnosis of asthma
- Significant airflow limitation (≤50% FEV1 predicted)
- Inability to cooperate with the required tests and measurements
- Recent infection or rejection within 1 month
- Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)
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Interventions
OTHERExercise
5 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing
OTHERExercise
15 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing
Locations(1)
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NCT07035743
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