Clinical Alternatives for Reducing Harm Using E-cigarettes
A Novel Harm Reduction Approach for Oncology Outpatients Who Smoke and Refuse Traditional Tobacco Treatment
Medical University of South Carolina
208 participants
Aug 25, 2025
INTERVENTIONAL
Conditions
Summary
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge. The proposed clinical trial will assess one harm reduction intervention, switching completely from cigarettes to e-cigarettes, among oncology outpatients who smoke and refuse traditional tobacco treatment. This study is a type 1 hybrid effectiveness-implementation trial among oncology outpatients at an NCI-designated cancer center who smoke and refuse all components of tobacco treatment (N=208).
Eligibility
Inclusion Criteria4
- age 21+,
- identified as smoking in their medical record and self-report of current smoking within the past 30 days
- refused traditional treatment options through the opt-out HCC Tobacco Treatment Program
- English speaking;
Exclusion Criteria4
- currently taking part in any TTP or using cessation medication (i.e., taking NRT or other cessation medications, enrolled in the Quitline, or in another study),
- use of e-cigarettes in the past 30 days,
- currently imprisoned,
- pregnant women.
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Interventions
Participants will be assigned to receive an e-cigarette and try to switch completely from smoking to using the e-cigarette
Participants will be assigned to receive tobacco treatment referrals and the opportunity to re-enroll in the Tobacco Treatment Program
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07039292