RecruitingNot ApplicableNCT07042087

Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness


Sponsor

St. Anne's University Hospital Brno, Czech Republic

Enrollment

48 participants

Start Date

Nov 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.


Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a combination of time-restricted eating (only eating during a limited daily window, such as 8 hours) and mindfulness practice can improve brain health and slow cognitive decline in older adults who already show early memory concerns. The trial lasts 9 months and targets people who show a biological marker linked to Alzheimer's risk. **You may be eligible if...** - You are between 60 and 80 years old - You have been diagnosed with subjective cognitive impairment (you notice memory problems) or mild cognitive impairment (MCI) - Your memory test score (MMSE) is between 24 and 30 - You have a positive blood test for pTau217, a marker associated with Alzheimer's risk - You are willing and able to participate in a 9-month program **You may NOT be eligible if...** - You have had a stroke or heart attack in the past year - You have serious uncontrolled health conditions (such as severe heart failure or unstable diabetes) - You are currently on GLP-1 medications (like Ozempic or Wegovy) - You have a condition that makes fasting or dietary changes unsafe - You cannot commit to the 9-month study duration Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMindfulness Yoga

A structured 9-month program integrating physical yoga postures (asanas), breathing techniques, sound, and meditation. Sessions are conducted twice weekly (90 minutes each) and focus on enhancing physical health, stress regulation, and cognitive performance. Delivered by certified instructors.

BEHAVIORALTime-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern

Participants follow a 16:8 time-restricted eating schedule (16 hours fasting / 8 hours eating window) for 9 months, with nutritional counseling promoting a flexitarian dietary pattern. The intervention is designed to support metabolic health and reduce risk factors for neurodegeneration.

BEHAVIORALCognitive Training

A 9-month structured program of twice-weekly cognitive training sessions (90 minutes each), targeting memory, attention, executive function, and social cognition using both paper-based and computer-based tasks. Supervised by trained therapists.

BEHAVIORALStretching

A twice-weekly stretching routine performed over 9 months (90-minute sessions), led by physiotherapists. This intervention provides low-intensity physical activity to control for physical engagement across study arms.


Locations(1)

Fnusa/ Icrc

Brno, Czechia

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NCT07042087


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