Natural History of Advanced Chronic Liver Diseases
Natural History of Advanced Chronic Liver Diseases and Factors Associated With Hepatic Events - a Registry Study
Chinese University of Hong Kong
500 participants
Sep 25, 2024
OBSERVATIONAL
Conditions
Summary
This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.
Eligibility
Inclusion Criteria4
- Aged 18 or above
- Known ACLD, defined by:
- LSM > 10kPa or
- Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy.
Exclusion Criteria6
- Current or past history of hepatocellular carcinoma (HCC)
- History of liver transplantation
- Asplenism or history of splenectomy
- Serious medical illness with limited life expectancy of less than 6 months
- Pregnancy
- Unable to obtain or refusal of informed consent from patient
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Interventions
Liver stiffness and spleen stiffness from transient elastography
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07042308