Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

This study is testing whether adding histotripsy — a non-invasive technique that uses focused ultrasound waves to physically destroy tumors — to standard chemotherapy improves outcomes for patients with colorectal cancer that has spread to the liver. The ultrasound waves break apart tumor tissue without surgery or radiation. **You may be eligible if...** - You have colorectal cancer liver metastases (cancer that has spread from the colon or rectum to the liver) - You have multiple liver tumors that cannot be completely removed by surgery - You are currently on or about to start first-line chemotherapy (5-FU based) - You may also have a small amount of disease in the lungs - You may have previously had other liver-directed treatments (such as ablation or embolization) **You may NOT be eligible if...** - Your liver tumors can be completely removed with surgery - You are not eligible for or not receiving chemotherapy - You have extensive disease outside the liver that would affect outcomes - Your overall health does not allow the procedure Talk to your doctor to see if this trial is right for you.