RecruitingNot ApplicableNCT07044596

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

Sponsor

University of Wisconsin, Madison

Enrollment

55 participants

Start Date

Nov 13, 2025

Study Type

INTERVENTIONAL

Conditions

Mild Traumatic Brain Injury Post-Concussion Syndrome

Summary

The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.

Eligibility

Min Age: 20 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Functional near-infrared spectroscopy (fNIRS), a medical device called MAGNUS scanner, and others for people with mild traumatic brain injury and post-concussion syndrome. The study is currently recruiting participants at 1 location. People eligible for this study include aged 20 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEFunctional near-infrared spectroscopy (fNIRS)

fNIRS is a non-invasive imaging technique which takes advantage of the light scattering and absorption differences between oxygenated (HbO) and de-oxygenated hemoglobin (HbDO) to characterize changes in cerebral hemodynamics in response to a given task or stimulus.

DEVICEV1 stimulation electrodes

The V1 electrodes will be placed on the forehead with some gel and held in place with a headband or cap (a conductive adhesive gel may be placed under the electrodes to help with stimulation). Participants will receive short electrical stimulations through these electrodes that will differ in intensity.

DEVICEMagnetic Resonance Imaging (MRI)

Participants will undergo 2 90-minute MRI sessions

DEVICEMAGNUS scanner

Simultaneous Coherent-Incoherent Motion Imaging (SCIMI) available on the MAGNUS scanner will be used to perform quality control and optimization in healthy volunteers, to better resolve and visualize slow CSF flows within the brain.