Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation

This study tests a specialized imaging technique called contrast-enhanced ultrasound (CEUS) — which uses tiny microbubbles injected into a vein to improve real-time imaging during brain surgery — to help surgeons more clearly see and remove brain tumors called gliomas. **You may be eligible if:** - You are between 18 and 95 years old - You are scheduled for standard brain surgery to remove a suspected or confirmed glioma (primary or recurrent) - You have adequate general health (WHO performance status ≤ 2) - Women of childbearing potential must have a negative pregnancy test **You may NOT be eligible if:** - You have had 2 or more brain surgeries in the past 3 months, or have a high risk of surgical site infection - You have a known allergy to the contrast agent used - You have a significant active infection - You have serious heart disease, severe high blood pressure, or pulmonary hypertension - You have sickle cell disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.