UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

This trial (UPBEAT) uses genetic information — specifically a "polygenic score" (a calculation based on your DNA) — to help decide whether beta-blocker medications would benefit people with heart failure whose heart pumping function is only mildly reduced. Not all heart failure patients respond equally to these medications, and researchers want to use genetics to guide treatment decisions. **You may be eligible if...** - You are 18–89 years old - You have been diagnosed with heart failure in the past year - Your heart's ejection fraction (pumping efficiency) is between 41% and 50% - You are not currently taking a beta-blocker at a significant dose **You may NOT be eligible if...** - Your ejection fraction has previously been 35% or lower - You are already on a high dose of a beta-blocker - Your blood pressure is uncontrolled or too low, or your heart rate is too slow - You have recently had a heart attack or heart procedure - You have had a heart transplant or a heart assist device - You are on dialysis or have end-stage kidney disease Talk to your doctor to see if this trial is right for you.