Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans
Jorge Gonzalez-Martinez
60 participants
May 10, 2022
INTERVENTIONAL
Conditions
Summary
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.
Eligibility
Inclusion Criteria2
- Movement disorder patients ≥18 years of age and \< 80 years of age, who will be implanted with DBS for treatment of motor symptoms.
- Subject has provided written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization, where applicable, prior to any study-related procedures.
Exclusion Criteria5
- History of seizure disorders
- Vasovagal response history and loss of consciousness history
- Severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator would impact participation in the study.
- Any serious disease or disorder (e.g. cancer, severe cardiac or respiratory disease, neurological conditions other than current movement disorder) or cognitive impairments that could impair ability to participate in this study.
- Females who are pregnant or breastfeeding.
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Interventions
All participants enrolled will undergo stimulation parameters tuning of deep brain stimulation electrode leads. All subjects will participate in a series of experiments to evaluate the stimulation effects on movement of face and upper extremities, swallowing, and speech abilities.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07056348