Brain Disease Clinical Trials

58 recruitingLast updated: June 18, 2026

There are 58 actively recruiting brain disease clinical trials across 25 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4. Top locations include Hong Kong, Hong Kong, Pittsburgh, Pennsylvania, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Brain Disease Trials at a Glance

58 actively recruiting trials for brain disease are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 29 trials, with the heaviest enrollment activity in Hong Kong, Pittsburgh, and Houston. Lead sponsors running brain disease studies include Chinese University of Hong Kong, Jorge Gonzalez-Martinez, and National Institute of Neurological Disorders and Stroke (NINDS).

Browse brain disease trials by phase

Treatments under study

About Brain Disease Clinical Trials

Looking for clinical trials for Brain Disease? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Brain Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Brain Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 58 trials

Recruiting

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

StrokeBrain DiseaseVascular Diseases+1 more
National Institute of Neurological Disorders and Stroke (NINDS)450 enrolled1 locationNCT06615973
Recruiting

Natural History of Stroke: Cause and Development

Brain DiseaseVascular DiseasesIschemic Attack, Transient+2 more
National Institute of Neurological Disorders and Stroke (NINDS)4,000 enrolled3 locationsNCT00009243
Recruiting
Phase 1Phase 2

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Breast NeoplasmsBreast DiseasesNeoplasms+5 more
Stemline Therapeutics, Inc.73 enrolled86 locationsNCT05386108
Recruiting
Not Applicable

Brain Connections for Arm Movement After Stroke

Cardiovascular DiseasesCentral Nervous System DiseasesStroke+2 more
VA Office of Research and Development76 enrolled1 locationNCT04286516
Recruiting

Inflammatory and Infectious Diseases of the Nervous System

Brain Disease
National Institute of Neurological Disorders and Stroke (NINDS)1,000 enrolled1 locationNCT02435810
Recruiting
Phase 1

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Not Applicable

Video Call Assisted Assessment of Acute Stroke

Brain DiseasesCentral Nervous System DiseasesStroke+3 more
University of Southern Denmark512 enrolled1 locationNCT06570681
Recruiting
Not Applicable

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Cardiovascular DiseasesCentral Nervous System DiseasesStroke+2 more
Jorge Gonzalez-Martinez10 enrolled1 locationNCT06303869
Recruiting
Not Applicable

Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly

ExerciseBrain DiseasesCognitive Decline+4 more
University Hospital, Grenoble64 enrolled1 locationNCT05048680
Recruiting

Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD

Parkinson DiseaseBrain DiseaseSynucleinopathies+2 more
Azienda USL Reggio Emilia - IRCCS150 enrolled1 locationNCT07187843
Recruiting
Not Applicable

Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia

DementiaBrain DiseasesCentral Nervous System Diseases+5 more
Advanced Technology & Communications180 enrolled11 locationsNCT06088121
Recruiting
Not Applicable

Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion

Brain DiseasesStrokeCerebrovascular Disorders+5 more
The Second Hospital of Anhui Medical University282 enrolled6 locationsNCT07185022
Recruiting
Phase 3

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting

Effective Translation of Endovascular Thrombectomy Trials Into Real-world Practice in the Asia-Pacific

Brain DiseasesStroke, IschemicStroke+3 more
Chinese University of Hong Kong350 enrolled3 locationsNCT05578300
Recruiting
Not Applicable

Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

Brain DiseasesCentral Nervous System DiseasesDepression+2 more
Centre Hospitalier Charles Perrens, Bordeaux200 enrolled1 locationNCT03678194
Recruiting

Impact of COVID-19 Vaccines on Cerebrovascular Health

DementiaBrain DiseasesStroke, Ischemic+7 more
Chinese University of Hong Kong500 enrolled1 locationNCT04992195
Recruiting

CUHK Brain Health Longitudinal Study

DementiaBrain DiseasesHealth Knowledge, Attitudes, Practice+9 more
Chinese University of Hong Kong5,000 enrolled2 locationsNCT03592563
Recruiting

Evaluation of a New MRI Technique to Reduce Breathing-Related Artifacts in Brain Imaging

Brain Diseases
Region Stockholm100 enrolled1 locationNCT07305948
Recruiting
Not Applicable

Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity

Brain DiseasesCentral Nervous System DiseasesParkinson Disease+7 more
University Hospital, Bonn130 enrolled1 locationNCT07324330
Recruiting

Rapamycin-Eluting Vertebral Stents In The Real-World Treatment of Symptomatic Intracranial Atherosclerotic Stenosis

Brain DiseasesIntracranial Arterial Stenosis
The Affiliated Hospital of Qingdao University300 enrolled1 locationNCT07352852