Posttraumatic Stress Disorder (PTSD) Clinical Trials

25 recruitingLast updated: June 18, 2026

There are 25 actively recruiting posttraumatic stress disorder (ptsd) clinical trials across 10 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4. Top locations include Houston, Texas, United States, Hong Kong, Hong Kong, Charleston, South Carolina, United States. Updated daily from ClinicalTrials.gov.


Posttraumatic Stress Disorder (PTSD) Trials at a Glance

25 actively recruiting trials for posttraumatic stress disorder (ptsd) are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Houston, Hong Kong, and Charleston. Lead sponsors running posttraumatic stress disorder (ptsd) studies include The University of Hong Kong, The University of Texas Health Science Center, Houston, and Medical University of South Carolina.

Browse posttraumatic stress disorder (ptsd) trials by phase

Treatments under study

About Posttraumatic Stress Disorder (PTSD) Clinical Trials

Looking for clinical trials for Posttraumatic Stress Disorder (PTSD)? There are currently 34 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Posttraumatic Stress Disorder (PTSD) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Posttraumatic Stress Disorder (PTSD) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 25 trials

Recruiting
Not Applicable

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

PregnancyPosttraumatic Stress Disorder (PTSD)
University of Texas at Austin60 enrolled1 locationNCT07060144
Recruiting
Not Applicable

Integrated Health Care for PTSD

Posttraumatic Stress Disorder (PTSD)
Veterans Medical Research Foundation300 enrolled5 locationsNCT07220681
Recruiting
Not Applicable

Efficacy of an EMDR App for PTSD and SUD

Substance Use DisordersPosttraumatic Stress Disorder (PTSD)
Centre for Addiction and Mental Health24 enrolled1 locationNCT07146633
Recruiting

Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders

Major Depressive Disorder (MDD)Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)
The University of Hong Kong300 enrolled1 locationNCT07604753
Recruiting
Not Applicable

Two-week Intensive Outpatient Trauma Treatment.

Posttraumatic Stress Disorder (PTSD)
Oslo University Hospital42 enrolled1 locationNCT07565311
Recruiting
Not Applicable

Mindfulness-based Stress Reduction for PTSD in Road Traffic Accident Victims: A Randomized Controlled Trial

Posttraumatic Stress Disorder (PTSD)
Universiti Sains Malaysia110 enrolled1 locationNCT07521020
Recruiting
Not Applicable

Transdiagnostic Metacognitive Therapy Compared to Disorder-Specific Cognitive-Behavioral Therapy for Anxiety Disorders

Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)Social Anxiety Disorder (SAD)
Karolinska Institutet86 enrolled1 locationNCT06937892
Recruiting

LHC-CIDI-5 in Hong Kong

Suicidal IdeationObsessive Compulsive Disorder (OCD)Major Depressive Disorder (MDD)+20 more
The University of Hong Kong2,500 enrolled1 locationNCT06804525
Recruiting
Not Applicable

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

Suicidal IdeationPosttraumatic Stress Disorder (PTSD)Suicide Attempt
Ohio State University190 enrolled1 locationNCT07238192
Recruiting
Phase 4

Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

Posttraumatic Stress Disorder (PTSD)
VA Office of Research and Development70 enrolled3 locationsNCT05776056
Recruiting
Phase 2

Ayahuasca, Esketamine and PTSD

Posttraumatic Stress Disorder (PTSD)
University of Sao Paulo10 enrolled1 locationNCT07317206
Recruiting
Phase 1

Inflammatory Challenge and Fear

Posttraumatic Stress Disorder (PTSD)
University of California, San Francisco288 enrolled1 locationNCT06630884
Recruiting
Not Applicable

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
The City College of New York15 enrolled1 locationNCT06872164
Recruiting
Not Applicable

Integrated Treatment for Opioid Use Disorder and PTSD

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
Medical University of South Carolina76 enrolled1 locationNCT06641115
Recruiting
Not Applicable

Project COMET: Massed Prolonged Exposure for PTSD and SUD

Posttraumatic Stress Disorder (PTSD)Trauma and Stressor Related DisordersSubstance Use Disorders (SUD)+1 more
Rutgers, The State University of New Jersey168 enrolled1 locationNCT06968832
Recruiting
Phase 2

A Study to Evaluate Effects on Sleep and Safety of RE03 in PTSD Patients With Sleep Disturbances

Sleep Disturbances and InsomniaPosttraumatic Stress Disorder (PTSD)
Reconnect Labs24 enrolled1 locationNCT06685965
Recruiting
Not Applicable

A Neurosensory Account of Anxiety and Stress (Study 1)

Posttraumatic Stress Disorder (PTSD)Intrinsic and Novelty-related Sensory Cortical (SC) Disinhibition
The University of Texas Health Science Center, Houston160 enrolled1 locationNCT05895006
Recruiting
Not Applicable

A Neurosensory Account of Anxiety and Stress (Study 2)

Posttraumatic Stress Disorder (PTSD)Threat-related Sensory Cortical (SC) Disinhibition
The University of Texas Health Science Center, Houston160 enrolled1 locationNCT07079839
Recruiting
Not Applicable

Treatment for PTSD and Tinnitus

PTSD - Post Traumatic Stress DisorderPosttraumatic Stress Disorder (PTSD)Tinnitus
The University of Texas Health Science Center at San Antonio160 enrolled1 locationNCT07106593
Recruiting

Evaluating Couple HOPES (i.e. Helping Overcome Posttraumatic Stress Disorder and Enhancing Satisfaction) within Australian first responders with Posttraumatic Stress Disorder and their partners.

Caregiver BurdenCaregiver BurnoutPosttraumatic Stress Disorder (PTSD)
Monash University42 enrolled1 locationACTRN12625000317493