RecruitingNot ApplicableNCT07062952

Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery

Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery: a Single-center Randomized Controlled Study(KISS Study)


Sponsor

Jinling Hospital, China

Enrollment

200 participants

Start Date

Apr 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection strategies for postoperative kidney tumor patients. lt will alsoassess the feasibility of salt substitute intervention. The primary research questions are: 1. Does a salt substitute diet significantly improve estimated glomerular filtration rate (eGFR) compared to a regular salt diet in postoperative kidney tumor patients? 2. What is the safety profile of salt substitute intervention in postoperative kidney tumor patients? 3. What is the compliance rate among postoperative kidney tumor patients using saltsubstitutes? 4. ls the salt substitute intervention feasible? Researchers will compare the intervention group (salt substitute diet) with the control group (regular salt diet) to determine whether salt substitutes effectively improve postoperative eGFR in kidney tumor patients. Participants will be required to: 1. Consume salt substitutes or regular salt daily while strictly adhering to WHO-recommendedsalt intake levels for 1 year. 2. Undergo scheduled baseline assessments at 1, 3, 6, and 12 months post-surgery, with 24-hoururine tests at months 1 and 6 to evaluate compliance. 3. Receive regular monitoring of blood electrolytes, eGFR, and other renal function indicators. 4. Document any adverse events or health status changes during the study period.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether switching to a low-sodium salt substitute at home can protect kidney function in people who have had surgery to remove a kidney tumor, since losing kidney tissue during surgery can reduce overall kidney function over time. **You may be eligible if...** - You are 18 years or older - You have had surgery to remove a kidney tumor (either full or partial kidney removal) - Your kidney function was normal before surgery (eGFR above 60) - Your blood potassium level is below 4.8 mmol/L - You cook most of your meals at home (90% or more) - All family members living with you are willing to participate **You may NOT be eligible if...** - Your kidney function was already reduced before surgery - You have high blood potassium levels - You have significant heart, lung, or liver problems - Your household members are not willing to use the salt substitute Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTSalt substitute

Patient consume salt substitutes daily while strictly adhering to WHO-recommendedsalt intake levels for 1 year.Salt substitutes (potassium-enriched low-sodium salt, primarily NaCl and KCl) reduce sodium content versus regular salt


Locations(1)

Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing

Nanjing, Jiangsu, China

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