Novel ROS-scavenging Nanoenzymes for the Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer

This study tests a nanoenzyme skin cream — tiny engineered particles that neutralize harmful free radicals — as a treatment for radiation dermatitis (a painful skin reaction) in people with head and neck cancer undergoing high-dose radiotherapy. **You may be eligible if...** - You have been diagnosed with a non-metastatic head and neck cancer confirmed by biopsy - You are scheduled to receive high-dose radiotherapy, either as your main treatment or after surgery **You may NOT be eligible if...** - You are in poor overall health (ECOG performance status above 2) - You already have an open skin wound, rash, or ulceration in the area to be treated - You have an inflammatory or connective tissue skin disorder - You have previously received radiation to the head or neck area Talk to your doctor to see if this trial is right for you.