ROS-Scavenging Nanozyme Combined With Thermotherapy Alleviate Radiation Dermatitis in Patients With Head and Neck Cancer

This study is testing a new topical treatment that combines a special antioxidant nanoparticle (ROS-scavenging nanozyme) with heat therapy to prevent and treat radiation dermatitis — the painful skin burns that commonly develop during radiation therapy in head and neck cancer patients. **You may be eligible if...** - You have been diagnosed with a head and neck cancer (non-metastatic, confirmed by pathology) - You are scheduled to receive high-dose radiotherapy, either as your primary treatment or after surgery **You may NOT be eligible if...** - Your overall health status is poor (ECOG performance status above 2) - You already have a skin rash, open wound, or ulceration in the treatment area - You are allergic to trolamine or Prussian blue (components of the treatment) - You have inflammatory or connective tissue skin conditions - You have previously received radiation to the head and neck area Talk to your doctor to see if this trial is right for you.