ROS-scavenging Amino Acid-derived Lipids for the Prevention and Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer

This study is testing a special skin cream made from amino acid-based lipids (natural building blocks of protein) to see whether it can prevent or treat radiation dermatitis — the painful skin inflammation, burns, and peeling that commonly occur during radiation therapy for head and neck cancers. **You may be eligible if...** - You have been diagnosed with a non-metastatic (not yet spread) head or neck cancer confirmed by biopsy - You are scheduled to receive high-dose radiation therapy as your primary treatment or after surgery **You may NOT be eligible if...** - You are very unwell and cannot tolerate treatment well (ECOG performance status above 2) - You already have a skin rash, wound, or open sore in the area that will be treated - You have a known allergy to trolamine or amino acids - You have an inflammatory skin condition in the treatment area - You have had prior radiation therapy to the head or neck Talk to your doctor to see if this trial is right for you.