RecruitingNot ApplicableNCT07065669

Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation


Sponsor

University of California, San Francisco

Enrollment

30 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents. The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD. Participants will: * visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments * have a brain MRI scan before TMS treatments begins and after finishing all TMS * complete questionnaires and report changes in behavior and physical symptoms


Eligibility

Min Age: 13 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) — where a magnetic device is placed near the scalp to gently stimulate brain activity — can help teenagers with moderate to severe obsessive-compulsive disorder (OCD). **You may be eligible if...** - You are between 13 and 17 years old - You have been diagnosed with OCD and symptoms are moderate to severe - You are an outpatient (not currently hospitalized) - You have been on a stable dose of any psychiatric medication or therapy for at least 8 weeks - A parent or legal guardian can provide consent on your behalf **You may NOT be eligible if...** - You have a history of schizophrenia, bipolar disorder, or significant substance use - You have a seizure disorder or serious brain condition - You have metal implants in or near your head - You are pregnant or nursing - You are currently at high risk for suicide Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDorsal medial Prefrontal Cortex intermittent theta burst stimulation

iTBS stimulation of the dmPFC is a FDA-approved treatment for adults with OCD

DEVICEcTBS to ROFC

continuous theta burst stimulation (cTBS) 1,800 pulses per session


Locations(1)

University of California, San Francisco

San Francisco, California, United States

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NCT07065669


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