Ropivacaine and Fentanyl for Labor Epidural Initiation
Determination of the 90% Effective Volume (ED90) of Epidural 0.1% Ropivacaine and Fentanyl for Labor Analgesia Initiation in Patients Receiving a Dural-Puncture Epidural Technique
University of California, San Francisco
50 participants
Oct 24, 2025
INTERVENTIONAL
Conditions
Summary
This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor. The study team will also study any side effects related to the epidural medication and patients' satisfaction with the quality of pain relief after receiving the epidural.
Eligibility
Inclusion Criteria4
- Patients with singleton vertex pregnancies in active labor (latent or spontaneous labor or after induction of labor)
- Cervical dilatation between 2 and 7 cm
- Requesting neuraxial labor analgesia
- Age 18 or older
Exclusion Criteria8
- Significant obstetric disease (e.g., pre-eclampsia, major cardiac disease)
- Chronic pain or chronic opioid use
- BMI ≥ 50
- Multiple gestations
- Allergy or anaphylaxis to local anesthetic
- Fetal compromise or non-reassuring fetal trace
- Age under 18
- Inability to speak and understand English or Spanish
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Interventions
A standard epidural admixture - 0.1% Ropivacaine + 2 mcg/ml fentanyl - will be used.
Locations(1)
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NCT07076368