Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders: a Single-arm Prospective Observational Study
Nicoletta C Machin
40 participants
Aug 8, 2025
OBSERVATIONAL
Conditions
Summary
This is a prospective, single-arm, single-center observational study evaluating the impact of intravenous (IV) iron replacement in patients with inherited bleeding disorders and iron deficiency (ferritin \<50ng/dL). Subjects will undergo baseline bleeding assessments, quality-of-life measures, and laboratory tests before receiving standard-of-care IV iron. Follow-up blood work and questionnaires will be conducted post-replacement to assess for changes
Eligibility
Inclusion Criteria6
- Males and Females > 15 years of age
- Diagnosed with an Inherited Bleeding Disorder (Von Willebrand disease, platelet disorders, factor deficiencies, or bleeding disorder of unknown cause)
- Evidence of Iron Deficiency (Ferritin < 50 ng/mL)
- Receiving IV iron at Hemophilia Center of Western Pennsylvania
- Willingness to have blood drawn
- Willing to return to clinic 3 months post infusion for final blood draw, bleeding and quality of life assessments.
Exclusion Criteria3
- Previous thrombosis, VTE History.
- Platelet count < 100,000 * 109/L
- Concomitant use of antiplatelet drugs, anticoagulants, aspirin, NSAIDs.
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Interventions
Participants will receive IV iron therapy as part of standard management for iron deficiency
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07083583