The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
King Abdullah International Medical Research Center
80 participants
Jul 15, 2025
INTERVENTIONAL
Conditions
Summary
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty. Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration
Eligibility
Inclusion Criteria3
- Patients undergoing knee joint arthroplasty.
- Saudi and Non-Saudi Patient.
- Patients who have Complete medical record.
Exclusion Criteria11
- End stage renal disease
- Liver cirrhosis
- Coagulopathy
- Pre-operative Hgb \<10 5.
- History of cerebrovascular accident or myocardial infarction in past 12 months.
- History of Heart failure.
- History of arrhythmia.
- History of pheochromocytoma, thyrotoxicosis and glaucoma.
- Pregnancy or breast feeding
- History of Deep venous thrombosis or pulmonary embolism
- Allergy to epinephrine or tranexamic acid
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
low-dose epinephrine and tranexamic acid
Tranexamic Acid
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07089251