RecruitingNot ApplicableNCT07091162

EValuation Of poLygenic Scores and CT imAging In Risk Factor Modification in Patients With diabEtes


Sponsor

Monash University

Enrollment

90 participants

Start Date

Jul 25, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a three-arm, parallel-group, randomised controlled trial evaluating the effect of using cardiac CT imaging or polygenic risk score in cardiovascular risk factor modification in patients with diabetes.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study (EVOLAIRE) combines genetic risk scoring (a polygenic risk score calculated from your DNA) with CT heart imaging to help doctors better guide how aggressively to manage cardiovascular risk factors in people with Type 2 diabetes. The goal is to personalize heart disease prevention. **You may be eligible if...** - You are 40 or older - You have a confirmed diagnosis of Type 2 diabetes - Your CT scan imaging quality is acceptable - A polygenic risk score can be calculated from your genetic data **You may NOT be eligible if...** - You already have known cardiovascular disease (e.g., prior heart attack or stroke) - Your CT scan shows significant coronary disease that already requires intervention - You are unable or unwilling to provide informed consent or attend follow-up visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCTCA results

Participants who are assigned to CTCA group will receive their CTCA results

OTHERPRS results

Participants who are assigned to PRS group will receive their PRS results


Locations(1)

Victorian Heart Hospital

Melbourne, Victoria, Australia

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NCT07091162


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