RecruitingNot ApplicableNCT06979232

Enhanced White Light Endoscopy Versus Conventional White Light Endoscopy for Colorectal Adenoma Detection: A Randomized Controlled Trial


Sponsor

Shanghai Jiao Tong University School of Medicine

Enrollment

800 participants

Start Date

Sep 20, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

1. Study on Adenoma Detection Rate (ADR) Comparing Enhanced White Light Endoscopy (E-WLI) versus Conventional White Light Endoscopy (WLI); 2. Study Comparing Enhanced White Light Endoscopy (E-WLI) versus Conventional White Light Endoscopy (WLI) for Detection Rates of Sessile Serrated Lesions (SSLs), Total Polyp Detection Rate, and Advanced Adenoma Detection Rate; 3. Study on Polyp Characteristics (Size, Location, etc.) Observed Using Conventional White Light Endoscopy (WLI) and Enhanced White Light Endoscopy (E-WLI).


Eligibility

Min Age: 45 YearsMax Age: 85 Years

Inclusion Criteria4

  • \. Male or female aged 45 to 85
  • \. Patients undergoing colonoscopy for colorectal cancer screening, positive fecal immunochemical test (FIT) results, gastrointestinal symptoms, or follow-up examination after colorectal polyp treatment
  • \. Capable of providing informed consent and agreeing to participate
  • \. Able and willing to follow all research processes

Exclusion Criteria11

  • \. Participated in other clinical trials, signed informed consent form, and in the follow-up period of other clinical trials;
  • \. Participated in clinical trials of drugs and is in the discontinuation period of experimental or control drugs;
  • \. Have had drug or alcohol abuse or psychological disorders in the past five years.
  • \. Pregnant or lactating patients;
  • \. Known to have polyposis syndrome;
  • \. Patients with gastrointestinal bleeding;
  • \. Previous history of inflammatory bowel disease, colorectal cancer, or colorectal surgery;
  • Patients with contraindications to tissue biopsy;
  • \. History of allergies to the ingredients in intestinal cleansers;
  • \. Individuals with conditions such as intestinal obstruction or perforation, toxic megacolon, heart failure (grade III or IV), severe cardiovascular disease, severe liver failure, or renal insufficiency, among others.
  • \. Researchers believe that patients are not suitable to participate in the trial.

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Interventions

DEVICEEnhanced White Light Imaging

Use of E-WLI for colon inspection during both insertion and withdrawal phase of colonoscopy

DEVICEWhite Light lmaging

Use of WLl for colon inspection during both insertion and withdrawal phase of colonoscopy


Locations(7)

Chongqing General Hospital

Chongqing, Chongqing Municipality, China

The First People's Hospital of Lanzhou City

Lanzhou, Gansu, China

The Third Affiliated Hospital of Heilongjiang University of Chinese Medicine

Harbin, Heilongjiang, China

Armed Police Forces Hospital of Sichuan

Leshan, Sichuan, China

People's Hospital of Bayingolin Mongol Autonomous Prefecture

Korla, Xinjiang, China

Ningbo Ninth Hospital

Ningbo, Zhejiang, China

Taizhou First People's Hospital

Taizhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT06979232


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