Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

This early-phase study is testing a new type of immune cell therapy — specially engineered natural killer (NK) cells — combined with radiation, in people with advanced head and neck cancer that has not responded to standard treatments. **You may be eligible if...** - You have been diagnosed with head and neck cancer that has spread or cannot be removed by surgery - Your cancer has come back or stopped responding to standard treatments - Your tumor tests positive for a protein called TROP2 - You are well enough to participate (good performance status) **You may NOT be eligible if...** - You received chemotherapy less than 2 weeks ago, or targeted therapy less than 3 days ago - You received a cell-based therapy (such as CAR-T) within the last 3 months - You have certain heart, liver, kidney, or lung problems that make treatment unsafe Talk to your doctor to see if this trial is right for you.