Visual Plasticity Following Brain Lesions
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
Georgetown University
30 participants
Jul 17, 2025
INTERVENTIONAL
Conditions
Summary
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.
Eligibility
Inclusion Criteria7
- A. Stroke, brain tumor, or traumatic brain injury patients
- At least 18 years of age.
- Capable of providing informed consent and complying with study procedures.
- Unilateral or bilateral focal brain damage causing loss of vision.
- At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
- At least 18 years of age.
- Capable of providing informed consent and complying with study procedures.
Exclusion Criteria7
- Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results.
- Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
- Vision loss resulting from ocular disease or disorder.
- B. Healthy volunteers (age-matched controls):
- Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results.
- Previous head injury.
- Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.
Interventions
Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz.
Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration.
A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07105358