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RecruitingNot ApplicableNCT07105358

Visual Plasticity Following Brain Lesions

Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training

Sponsor

Georgetown University

Enrollment

30 participants

Start Date

Jul 17, 2025

Study Type

INTERVENTIONAL

Conditions

Traumatic Brain InjuryBrain TumorStrokeHemianopiaVisual Field DefectQuadrantanopiaCortical BlindnessVisual Field Defect, Peripheral

Summary

The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether vision can partially recover after brain damage — such as from stroke, brain tumor, or traumatic brain injury — using a structured visual training program. **You may be eligible if...** - You are 18 or older - You have had a stroke, brain tumor, or traumatic brain injury that caused vision loss - It has been at least 3 months since your stroke or injury, or your brain tumor has been stable for the past year - You are able to give informed consent and follow study instructions - (Healthy volunteers without brain injury may also be eligible as controls) **You may NOT be eligible if...** - You have other serious brain or neurological conditions unrelated to your injury - You have a serious mental health condition or active substance abuse - Your vision loss is due to an eye disease (not a brain injury) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEtranscranial random noise stimulation (tRNS)

Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz.

DEVICESham Stimulation

Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration.

BEHAVIORALPerceptual learning-based training

A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels.

Locations(1)

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

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NCT07105358

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