RecruitingNot ApplicableNCT07111390

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

A Feasibility Pilot Study of Home-Based Intermittent 60Hz Light Therapy for the Treatment of Depression


Sponsor

NYU Langone Health

Enrollment

40 participants

Start Date

Aug 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE). Participants will be randomized in a 2:1 ratio to receive either active or sham 60Hz intermittent light stimulation for 30 minutes daily (Monday through Friday) over three weeks. The light is delivered through a wearable headset. Clinical assessments will be conducted remotely at baseline, mid-point, post-treatment, and follow-up to measure changes in depressive symptoms.


Eligibility

Min Age: 24 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a home-based light therapy device that flickers at 60 Hz can improve symptoms in people with major depressive disorder (MDD) who are not fully responding to antidepressant medication. Light-based treatments are thought to influence brain rhythms involved in mood regulation. **You may be eligible if...** - You are between 24 and 65 years old - You have a confirmed diagnosis of major depressive disorder - Your depression score is in the moderate-to-severe range (score of 17 or above on a standard scale) - You have been on a stable antidepressant medication for at least 30 days - You have access to a quiet space at home for the sessions - You have a local doctor or provider overseeing your care - You are English-speaking **You may NOT be eligible if...** - You have a neurological or autoimmune disorder - You have another psychiatric condition such as bipolar disorder, OCD, PTSD, psychosis, or anxiety disorder - You have a current or recent substance use disorder - You have had prior manic episodes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICE60Hz Intermittent Light Therapy

Intermittent 60 Hz flickering white light delivered via a wearable headset.

DEVICESham Light Therapy

Constant white light delivered via a wearable headset.


Locations(1)

NYU Langone Health

New York, New York, United States

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NCT07111390


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