ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
ProspEXPO : PROSPective Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
University Hospital, Angers
300 participants
Dec 17, 2025
INTERVENTIONAL
Conditions
Summary
The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition, physical activity, socio-demographic conditions, tobacco, alcohol, pollutants) on the occurrence of the main type of liver cancer (called HCC). Indeed, in the vast majority of cases, HCC develops within cirrhosis, and the factors that precipitate the progression of cirrhotic patients to HCC remain largely unknown.
Eligibility
Inclusion Criteria4
- Presence of metabolic and/or alcoholic steatotic liver disease, as defined by the new nomenclature (MASLD, ALD, or mixed MetALD)
- Liver biopsy performed (less than 2 months ago) or planned as part of treatment for diagnosis of cirrhosis ("Control" group without HCC) or diagnosis of HCC on cirrhosis ("Case" group)
- Patient affiliated to or benefiting from a social security scheme
- Patient having signed an informed consent to participate in the study (bio-collection)
Exclusion Criteria5
- Causes of chronic liver disease other than MASLD, ALD, or MetALD
- Decompensation of cirrhosis in the two years prior to inclusion (ascites, hepatic encephalopathy, gastrointestinal variceal hemorrhage, liver failure, hepatorenal syndrome)
- For the "Control" group: history of hepatocellular carcinoma
- Pregnant, breast-feeding or parturient women
- Persons deprived of liberty by judicial or administrative decision
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Interventions
Collection of blood, urine and stool sampling in order to build up a biocollection
Locations(4)
View Full Details on ClinicalTrials.gov
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NCT07119957