STICH3C Cardiac Magnetic Resonance Observational Study
STICH3C Cardiac Magnetic Resonance (CMR) Observational Study (STICOS)
Weill Medical College of Cornell University
200 participants
Mar 1, 2024
OBSERVATIONAL
Conditions
Summary
STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovascular events such as heart failure , readmission, or death. This study will look at whether certain heart tissue abnormalities seen on MRI scans can help predict serious health problems after heart procedures like stents or bypass surgery.
Eligibility
Inclusion Criteria4
- Men and women ≥ 18 years old
- LVEF ≤ 40% (quantified by echo, single-photon emission computed tomography \[SPECT\], or CMR within 2 months of enrollment)
- Prognostically important CAD: either multivessel CAD (triple vessel or double vessel CAD including left anterior descendant artery (LAD), significant coronary stenosis defined as ≥ 70% based on coronary angiography, fractional flow reserve (FFR) ≤ 0.80 or instantaneous wave-free ratio (iFR) ≤ 0.89) or left main disease (+/- other CAD) for which significant stenosis defined as > 50% based on coronary angiography, intravascular ultrasound (IVUS) minimum luminal area \[MLA\] value ≤ 6.0 mm2 (< 4.5 mm2 Asian descent), or equivalent optical coherence tomography (OCT) measurements.
- Planned CABG or PCI within 3 months
Exclusion Criteria4
- Concomitant valve disease or other condition (e.g., LV aneurysm) requiring surgical repair or replacement
- Contraindication to CMR (i.e. magnetically activated materials), gadolinium, regadenoson/adenosine/dipyridamole
- Active neoplasm and/or severe end-organ dysfunction with expected life expectancy less than 5 years.
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Interventions
Cardiac MRI, also known as cardiac magnetic resonance imaging, is a non-invasive imaging technique that uses strong magnetic fields and radio waves to produce detailed pictures of the heart and its surrounding structures
Locations(9)
View Full Details on ClinicalTrials.gov
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NCT07133984