Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism

This study is looking at whether adding spironolactone (a medication that blocks a hormone called aldosterone) to standard blood pressure treatment works better than standard treatment alone in people with a condition called primary aldosteronism — a hormonal disorder that causes high blood pressure. **You may be eligible if...** - You are 30 to 65 years old - You have been diagnosed with primary aldosteronism (confirmed by specific tests) - You have high blood pressure that has not been adequately controlled - You either declined surgery or are not a candidate for surgery **You may NOT be eligible if...** - You have high potassium levels in your blood (hyperkalemia) - You have significant kidney disease - You are pregnant or breastfeeding - You have serious heart problems (such as heart failure or recent heart attack) - You have certain other hormonal conditions affecting the adrenal glands Talk to your doctor to see if this trial is right for you.