Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

This study is evaluating how well radiofrequency ablation (RFA) — a minimally invasive procedure that uses heat to destroy abnormal tissue — works for treating benign (non-cancerous) thyroid nodules, indeterminate nodules, low-risk thyroid cancers, and locally recurrent thyroid cancer in patients who cannot have or prefer to avoid surgery. **You may be eligible if...** - You are over 18 years old - You have a thyroid nodule or low-risk thyroid cancer that has been confirmed by biopsy - Your nodule is causing symptoms (pressure in the neck, visible swelling) or you have a concerning nodule type - You are not a surgical candidate or have declined surgery **You may NOT be eligible if...** - Your thyroid cancer has spread to lymph nodes or distant organs - You have had prior neck radiation - You have a pacemaker or other implanted device incompatible with RFA - You are pregnant Talk to your doctor to see if this trial is right for you.