Microplastic Analysis in Pediatric Inflammatory Bowel Disease
Analysis of Microplastics in Pediatric Inflammatory Bowel Disease Using Raman Spectroscopy: A Multi-Matrix Study
Medical University of Gdansk
40 participants
Jun 15, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD. The main questions it aims to answer are: Are microplastics detectable in different biological samples from children? Are there differences in microplastic burden between children with and without IBD? Researchers will collect biological samples including: intestinal tissue (from routine endoscopy), stool, urine, blood. Raman spectroscopy will be used to detect and characterize microplastics in each sample type. Participants will not receive any medication or intervention as part of this study. All samples will be collected during standard clinical procedures.
Eligibility
Inclusion Criteria4
- Age \<18 years
- Undergoing clinically indicated gastrointestinal endoscopy
- For IBD group: confirmed diagnosis of Crohn's disease or ulcerative colitis
- For control group: no current or past diagnosis of IBD
Exclusion Criteria3
- Age 18 years or older
- Lack of informed consent from legal guardian
- Lack of written assent from the participant if age ≥13 years
Interventions
Exposure to environmental microplastics measured by their presence in intestinal tissue, blood, urine, and stool using Raman spectroscopy. This study does not assign any exposure or treatment; it investigates the existing presence of microplastics as an environmental factor of interest.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07141238