Anastomotic Leak Clinical Trials

29 recruitingLast updated: June 18, 2026

There are 29 actively recruiting anastomotic leak clinical trials across 14 countries. Studies span Not Applicable. Top locations include Nanchong, Sichuan, China, Houston, Texas, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Anastomotic Leak Trials at a Glance

29 actively recruiting trials for anastomotic leak are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Nanchong, Houston, and New York. Lead sponsors running anastomotic leak studies include Nanchong Central Hospital, Khyber Teaching Hospital, and Aesculap AG.

Browse anastomotic leak trials by phase

Treatments under study

About Anastomotic Leak Clinical Trials

Looking for clinical trials for Anastomotic Leak? There are currently 15 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anastomotic Leak trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anastomotic Leak clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 29 trials

Recruiting

Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy

Esophageal CarcinomaEsophageal AdenocarcinomaEsophagectomy+2 more
Sun Yat-sen University2,500 enrolled6 locationsNCT07309991
Recruiting
Not Applicable

Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections

Postoperative ComplicationsAnastomotic LeaksAnastomotic Complication+8 more
Medtronic - MITG137 enrolled9 locationsNCT07351071
Recruiting

Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy

Colon CancerAnastomotic LeakRight Hemicolectomy
Aesculap AG249 enrolled4 locationsNCT07132970
Recruiting

Endoscopic COlorectal Mucosal Evaluation of Oxygen Tension

Anastomotic Leak RectumAnastomotic Leak Large Intestine
Vanderbilt University Medical Center80 enrolled1 locationNCT07467980
Recruiting
Not Applicable

Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection

Rectal CancerAnastomotic Leakage
Tongji Hospital72 enrolled3 locationsNCT07605611
Recruiting

Anastomotic Leakage After Colorectal Surgery.

Colorectal, CancerAnastomotic LeakDiverticulitis
Minia University430 enrolled1 locationNCT07144683
Recruiting
Not Applicable

The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal Cancer

Anastomotic Leakage
Nanchong Central Hospital140 enrolled1 locationNCT07588386
Recruiting
Not Applicable

Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area

Anastomotic LeaksHartmanns Stump Leakage
Boston Scientific Corporation66 enrolled8 locationsNCT07035431
Recruiting
Not Applicable

Efficacy and Safety of Colorectal Anastomotic Leak Testing

Colorectal, CancerColorectal SurgeryComplications+2 more
Nanchong Central Hospital264 enrolled1 locationNCT06865638
Recruiting
Not Applicable

Stapler Reinforcement Patches Compared to Standard Staplers in Gastrojejunostomy

Gastric CancerPostoperative ComplicationsGastrostomy+1 more
Nanchong Central Hospital382 enrolled1 locationNCT06464978
Recruiting
Not Applicable

Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery

Colorectal, CancerColorectal SurgeryComplications+2 more
Nanchong Central Hospital110 enrolled1 locationNCT07208786
Recruiting
Not Applicable

CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery

Colorectal SurgeryAnastomotic LeakEnhanced Recovery+2 more
Centre Hospitalier Universitaire, Amiens500 enrolled1 locationNCT07464600
Recruiting

Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak

Anastomotic LeakEsophageal Malignant Neoplasm Primary
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT07449208
Recruiting

Single-Stapled Technique for Colorectal Anastomosis

Colorectal, CancerColorectal AnastomosisAnastomotic Leakage+1 more
Umeå University500 enrolled5 locationsNCT07417358
Recruiting

Impact of Endo-vac Therapy for Esophago-jejunal Anastomotic Leak

Esophagojejunal Anastomotic Leak
Ukrainian Society of Clinical Oncology100 enrolled1 locationNCT07295236
Recruiting
Not Applicable

Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer

Quality of LifeRectal NeoplasmsLow Anterior Resection Syndrome+1 more
Sixth Affiliated Hospital, Sun Yat-sen University256 enrolled1 locationNCT05943444
Recruiting

Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer

Esophageal CancerEsophagus CancerAnastomotic Leak
Aesculap AG44 enrolled1 locationNCT06097078
Recruiting
Not Applicable

A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks Detection

Colorectal SurgeryAnastomotic Leak
Exero Medical Ltd.190 enrolled13 locationsNCT06168669
Recruiting
Not Applicable

Outcomes of a Single Chest Drain vs Two Drains

Esophageal AdenocarcinomaPleura; EffusionEsophageal Anastomotic Leak
Khyber Teaching Hospital68 enrolled1 locationNCT07125248
Recruiting

Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer

Anastomosis; ComplicationsAnastomosis, SurgicalAnastomosis, Leaking+8 more
Saint Camillus International University of Health Sciences100 enrolled1 locationNCT07099820