Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy

This study is testing whether a specific probiotic supplement can improve the balance of bacteria in the gut and vagina in women with advanced or recurrent ovarian cancer who are receiving platinum-based chemotherapy (a common cancer treatment). Researchers want to see if improving the microbiome helps reduce side effects or improves outcomes. **You may be eligible if...** - You are 18 years or older - You have advanced (stage II–IV) or recurrent ovarian cancer and will be receiving platinum-based chemotherapy as standard care - You are willing to avoid other probiotic or prebiotic supplements during the study - You agree not to make major dietary changes during the study **You may NOT be eligible if...** - You have a borderline (low-grade) ovarian tumor - You have a prior allergy or intolerance to probiotic products - You have chronic inflammation or structural problems in your digestive tract (e.g., inflammatory bowel disease requiring medication, active ulcers, bowel obstruction) - Your blood counts are too low to safely receive platinum chemotherapy - You have a known allergy to any ingredient in the study probiotic product or to multiple antibiotics that target the bacterial strains used Talk to your doctor to see if this trial is right for you.