RecruitingPhase 4NCT07154719

GLP-1R Actions on Muscle and the Skeleton

Sponsor

Pennington Biomedical Research Center

Enrollment

50 participants

Start Date

Oct 9, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity Osteoporosis Drug Effect Sarcopenic Obesity Musculoskeletal Abnormalities

Summary

The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Lifestyle toolkit and a drug called Tirzepatide for people with drug effect, musculoskeletal abnormalities, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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