Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
University of Minnesota
160 participants
Feb 4, 2026
INTERVENTIONAL
Summary
The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals under buprenorphine maintenance treatment for OUD (bOUD).
Eligibility
Inclusion Criteria4
- ability to provide consent and comply with study procedures
- Diagnostic and Statistical Manual of Mental Disorders criteria for OUD
- undergoing buprenorphine maintenance treatment. Participants may have current comorbid drug use, but primary diagnosis must be OUD
- Intention to remain in the addiction treatment program until intervention completion.
Exclusion Criteria10
- Any medical condition with neurological sequelae
- head injury resulting in skull fracture or loss of consciousness of >30 minutes
- any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia)
- any psychotic disorder (participants with other treated and stable psychiatric disorders will be included)
- presence of a condition that would render study measures impossible to administer or interpret
- age younger than 18
- primary current substance use disorder on a substance other than opioids except for caffeine or nicotine
- court mandated treatment
- pregnancy
- disrespectful behavior towards the investigators and staff.
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Interventions
We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).
electrodes will have the same montage as active tDCS (F3/F4), but current will be ramped down after the initial 30 seconds ramp-up period. Thus, participants will feel the initial sensation associated with tDCS but will receive no active current for the rest of the stimulation period.
Locations(1)
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NCT07158853