RecruitingNot ApplicableNCT07160621

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

Sponsor

St. Jude Children's Research Hospital

Enrollment

228 participants

Start Date

Sep 5, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Pain Childhood Cancer Survivor

Summary

The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in adolescent survivors of pediatric cancer. This randomized study led by St. Jude Children's Research Hospital will involve 228 participants (114 adolescent survivors and 114 caregivers) across four U.S. hospitals. Outcomes include pain reduction, improved function, and the role of social determinants of health. Assessments occur at baseline, post-treatment, and 3-month follow-up.

Eligibility

Min Age: 10 YearsMax Age: 17 Years

Inclusion Criteria8

Adolescent Participants
-17-year-old survivors of childhood cancer or those who received cancer directed therapies (e.g., Langerhan's Histiocytosis)
At least one-year post treatment completion
Pain present for 3 months or longer
Pain interfering with at least one area of daily functioning
Parent/Caregiver Participants
≥ 18 years of age
Legally authorized to provide informed consent for the adolescent participant

Exclusion Criteria8

Adolescent Participants
Serious comorbid psychiatric condition
Current substance abuse as determined by the Substance Use Screening Questionnaire
History of development delay or significant cognitive impairment
Note: A participant who completed the feasibility study (ADAPTED) cannot participate in the subsequent clinical trial (ADAPTED2)
Parent/Caregiver Participants
Not fluent in English or Spanish
Unable to provide consent for own participation or for the participation of the adolescent participant