Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial
Tanta University
45 participants
Sep 11, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.
Eligibility
Inclusion Criteria3
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
Exclusion Criteria12
- Severe cardiovascular problems.
- Respiratory disorders.
- Diabetes.
- Hypertension.
- Obesity.
- Allergic reaction to study drugs.
- Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
- Medications that affect heart rate (HR) or blood pressure (BP).
- Pregnant.
- Currently breast-feeding women.
- History of sleep apnea.
- Those for emergency procedures.
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Interventions
Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.
Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.
Patients will receive saline before induction of anesthesia as a control group.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07165483