Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Impact of Intranasal Dexmedetomidine-esketamine Administration on Postoperative Pain in Pediatric Patients Undergoing Adenotonsillectomy: a Randomized, Placebo-controlled Trial
Peking University First Hospital
160 participants
Apr 7, 2026
INTERVENTIONAL
Conditions
Summary
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain. Currently, there is a lack of clinical strategies to safely and effectively manage postoperative pain in children undergoing adenoid and tonsil surgery. Dexmedetomidine and esketamine can achieve appropriate sedation levels and alleviate postoperative pain when used in children. Both drugs can be administered intranasally, and their pharmacological effects complement each other, reducing side effects. This study aims to investigate whether intranasal administration of dexmedetomidine-esketamine combination can improve postoperative analgesia in children undergoing adenoid and tonsil surgery.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
A mixture of dexmedetomidine-esketamine combination will administered intranasally after anesthesia induction.
Placebo (normal saline) will administered intranasally after anesthesia induction.
Locations(1)
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NCT07479602