Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
Emory University
84 participants
Feb 13, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users. Primary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.
Eligibility
Inclusion Criteria5
- Current established users of nicotine pouches (have used nicotine pouches in the past 30 days \& currently use nicotine pouches every day or someday)
- Positive cotinine test via saliva test strip
- Those who are unmotivated to quit nicotine use
- Read and speak English.
- Poly-users of nicotine pouches, e-cigarettes (e.g., vape ≥20 days/month), and tobacco (e.g., ≥4 cigarettes/day for ≥2 years) will be eligible for participation
Exclusion Criteria3
- Planning to cut down or quit using nicotine in the next 30 days
- Currently pregnant or breastfeeding
- History of stroke, seizures, high blood pressure, heart disease/problems, or cardiovascular disease contraindications for nicotine.
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Interventions
Nicotine pouch: 3-4 mg
Nicotine pouch: 6-8 mg
Nicotine pouch with low pH level \[\<8.5\]
Nicotine pouch with high pH level \[\>8.5\]
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07165808