Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy

This trial is testing whether cannabidiol (CBD) — a non-psychoactive compound from cannabis — can prevent or reduce nerve damage (neuropathy) caused by oxaliplatin, a common chemotherapy drug used in colon cancer treatment. Oxaliplatin-induced neuropathy causes numbness, tingling, and pain in the hands and feet, and there is currently no reliable preventive treatment. **You may be eligible if...** - You have metastatic or locally advanced colorectal cancer that cannot be removed surgically - You are planned to receive oxaliplatin-based chemotherapy for at least 3 months - You have no prior nerve damage (neuropathy) - You have not previously been treated with platinum-based chemotherapy - Your liver and overall organ function meet required levels **You may NOT be eligible if...** - You already have nerve damage of any kind - You have had prior oxaliplatin or other platinum chemotherapy - You have significant liver dysfunction - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.