Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
Laval University
30 participants
Oct 21, 2025
INTERVENTIONAL
Conditions
Summary
Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.
Eligibility
Inclusion Criteria4
- ≥ 18 years of age
- Admiitted in intensive care unit
- Presence of an arterial catheter
- Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .
Exclusion Criteria5
- No SpO2 signal with oximeter in use
- False nails or nail polish
- Methemoglobinemia \>0.015 on last available arterial gas
- Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)
- Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)
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Interventions
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07168213