Acute Respiratory Failure Clinical Trials

49 recruitingLast updated: June 17, 2026

There are 49 actively recruiting acute respiratory failure clinical trials across 41 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Madrid, Spain, Montpellier, France, Izmir, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Acute Respiratory Failure Trials at a Glance

49 actively recruiting trials for acute respiratory failure are listed on ClinicalTrialsFinder across 6 cities in 41 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Madrid, Montpellier, and Izmir. Lead sponsors running acute respiratory failure studies include University of Modena and Reggio Emilia, Assistance Publique - Hôpitaux de Paris, and Dr. Behcet Uz Children's Hospital.

Browse acute respiratory failure trials by phase

Treatments under study

About Acute Respiratory Failure Clinical Trials

Looking for clinical trials for Acute Respiratory Failure? There are currently 38 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Acute Respiratory Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Acute Respiratory Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 49 trials

Recruiting
Not Applicable

Simulation Trial of Telemedical Support for Paramedics

Acute Respiratory FailureEmergenciesCardiopulmonary Arrest+1 more
Boston Medical Center420 enrolled9 locationsNCT06441760
Recruiting
Not Applicable

Effect of High Flow Nasal Therapy (HFNC) Weaning Protocols vs Standard of Care on Respiratory Outcomes in Patients With Acute Respiratory Failure

Acute Respiratory Failure (ARF)
University of Milan148 enrolled2 locationsNCT07638293
Recruiting
Phase 4

Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure

Acute Respiratory FailureKidney Transplant RecipientsSepsis and septic shock+1 more
University Hospital, Strasbourg, France212 enrolled1 locationNCT06881927
Recruiting
Not Applicable

Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients on Non Invasive Respiratory Support

Non-invasive ventilationAcute Respiratory Failure (ARF)
Queen Mary University of London50 enrolled2 locationsNCT07423338
Recruiting
Not Applicable

Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.

Acute Respiratory Failure
Hospices Civils de Lyon20 enrolled1 locationNCT07532811
Recruiting

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure
Brian Driver2,092 enrolled9 locationsNCT06934876
Recruiting

Brain-lung Interaction During Acute Respiratory Failure

Acute Respiratory Failure
Assistance Publique - Hôpitaux de Paris25 enrolled2 locationsNCT07279831
Recruiting

A Clinical Study for Developing Artificial Intelligence(AI)-Based Clustering Model for Personalized Medicine in Acute Respiratory Failure

Acute Respiratory Failure
Samsung Medical Center250 enrolled1 locationNCT06479421
Recruiting

The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study

Acute Respiratory Distress Syndrome (ARDS)Acute Respiratory FailurePneumonia+2 more
First Affiliated Hospital of Wannan Medical College41 enrolled1 locationNCT07542366
Recruiting
Not Applicable

Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.

De Novo Hypoxemic Acute Respiratory Failure (hARF)
Assistance Publique - Hôpitaux de Paris1,084 enrolled29 locationsNCT06213168
Recruiting

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

Acute Respiratory FailureCritical Illness
The Institute of Molecular and Translational Medicine, Czech Republic200 enrolled2 locationsNCT06189924
Recruiting
Not Applicable

Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy

Acute Respiratory FailureOxygen DeliveryHigh Flow Oxygen Therapy+1 more
Laval University30 enrolled1 locationNCT07168213
Recruiting
Phase 3

Optimizing Pain Treatment in Children On Mechanical Ventilation

Mechanical VentilationSedation and AnalgesiaAnalgesics, Opioid+1 more
Weill Medical College of Cornell University644 enrolled15 locationsNCT06994442
Recruiting

Investigating Dyadic Expectations About ARF Survivorship (IDEAS)

Mental Health IssueAcute Respiratory FailureCaregiving Stress
Johns Hopkins University235 enrolled1 locationNCT06401239
Recruiting

Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Acute Respiratory Failure (ARF)
Peking Union Medical College Hospital50 enrolled1 locationNCT07379242
Recruiting
Not Applicable

Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)

Acute Respiratory Failure Requiring Intubation
Nantes University Hospital710 enrolled10 locationsNCT06307392
Recruiting

Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure

Acute Respiratory Failure
Hospices Civils de Lyon250 enrolled4 locationsNCT05347563
Recruiting

CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure

Acute Respiratory Failure
University of Modena and Reggio Emilia325 enrolled1 locationNCT06989385
Recruiting
Not Applicable

Global Physiotherapy in ICU Patients With High Risk Extubation Failure

Acute Respiratory Failure
University Hospital, Bordeaux256 enrolled1 locationNCT05423301
Recruiting
Not Applicable

Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure

Chronic respiratory failureAcute Respiratory Failure
Aether Tech S.L.20 enrolled2 locationsNCT06952816