Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.

This trial is testing a new non-invasive sputum (mucus) test to detect lung cancer in people who are at high risk because they have a lung nodule found on a CT scan. You may be eligible if... - You are between 50 and 80 years old - You are a current or former smoker with at least 20 pack-years of smoking history (you quit within the past 15 years if a former smoker) - You have a lung nodule between 6 and 30 mm found on a CT scan - You are able to cough up a sputum (mucus) sample You may NOT be eligible if... - You cannot produce a sputum sample due to severe lung disease - Your nodule is a specific type (ground glass or mostly ground glass) or in certain locations - You are immune-suppressed, have rheumatoid arthritis, or have been diagnosed with lung cancer in the past 5 years or another cancer in the past 2 years - You have angina with minimal physical effort - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.