RecruitingNot ApplicableNCT07465848

Prospective Multicentre Study for the Application of Telomere Measurement Technology as a Tool for Lung Cancer Diagnosis


Sponsor

Grupo Español de Investigación en Diagnóstico y Tratamiento Hipertemprano de Enfermedades (GeDiTPhe)

Enrollment

1,200 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This research is a clinical performance study of in vitro diagnostic device (IVD), a prospective, multicentre, open-label, case-control clinical investigation aimed at constructing a predictive model that allows results to be classified as positive or negative in relation to the probability of having lung cancer.


Eligibility

Min Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether measuring the length of telomeres — protective caps at the ends of chromosomes that shorten as cells age — in blood samples can help detect lung cancer earlier. Researchers hope this could become a simple blood-based screening tool. **You may be eligible if...** - You are 45 years or older - You have been newly diagnosed with small-cell or non-small-cell lung cancer and have not started treatment yet (case group) - OR you are a high-risk individual who smokes or has smoked heavily and has no cancer diagnosis (control group A) - OR you are a lower-risk individual with no cancer diagnosis (control group B) **You may NOT be eligible if...** - You have already started cancer treatment (surgery, chemotherapy, radiation, or immunotherapy) before sample collection - You are under 45 years old - You do not meet the risk profile for the control group you are being enrolled in Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTBlood sample collection for telomere biomarker analysis

Peripheral blood samples will be collected to measure telomere-related biomarkers that will be used for the development of a predictive algorithm.

DIAGNOSTIC_TESTTelomere biomarker analysis

Laboratory analysis of telomere-associated biomarkers in blood samples to generate data for the development of a predictive clinical algorithm.


Locations(12)

Hospital General Universitario de Elche

Elche, Alicante, Spain

Hospital del Mar

Barcelona, Barcelona, Spain

Institut Catalá D'Oncologia Badalona (ICO)

Barcelona, Barcelona, Spain

Hospital Universitario Marqués de Valdecilla

Santander, Cantabria, Spain

Clínica Universidad de Navarra

Madrid, Madrid, Spain

HM Sanchinarro/CIOCC

Madrid, Madrid, Spain

Hospital Universitario 12 Octubre

Madrid, Madrid, Spain

Hospital Universitario Clínico San Carlos

Madrid, Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Madrid, Spain

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Complejo Hospitalario de Toledo

Toledo, Toledo, Spain

Hospital Universitari I Politècnic La Fe

Valencia, Valencia, Spain

View Full Details on ClinicalTrials.gov

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NCT07465848


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