RecruitingNot ApplicableNCT07172295

Modulate Tremor Severity With Low-intensity Focused Ultrasound Stimulation Targeting the Deep Nucleus of Patients With Refractory Hand Tremor.

Sponsor

National Taiwan University Hospital

Enrollment

12 participants

Start Date

Jun 11, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease (PD)Essential Tremor Dystonic Tremor Continuous Theta Burst Stimulation Transcranial Focused Ultrasound

Summary

The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a non-invasive brain stimulation technique called low-intensity focused ultrasound to try to reduce hand tremors in people with Parkinson's disease, essential tremor, or dystonia whose tremors have not improved enough with medication. **You may be eligible if...** - You are between 18 and 80 years old - You have Parkinson's disease, essential tremor, or dystonic tremor with hand tremors that have not responded adequately to medication - Your medications have been stable for at least 4 weeks - You are willing to shave the hair over the treatment area on your head **You may NOT be eligible if...** - You have metal implants in your head (e.g., aneurysm clips, cochlear implants, deep brain stimulator, pacemaker) - You are pregnant or unable to use contraception during and after the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAccelerated NaviFUS-ctbFUS stimulation

Three consecutive sessions of NaviFUS-ctbTUS stimulation were performed, with a 5-minute interval between each session. The acoustic pressure was set such that the estimated intracranial pressure at 30% skull transmission was approximately 0.5 MPa. The stimulation target was the center of the Vop, with a total of 7 stimulation points.