RecruitingNot ApplicableNCT07173504

The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients

Sponsor

Gelderse Vallei Hospital

Enrollment

124 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Critical Illness

Summary

The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients. The aim of this study is to: • To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition. Participants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age ≥18 years;
Receiving or eligible to receive exclusively gastric tube feeding;
Expected ICU stay ≥48 hours;
Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission.

Exclusion Criteria7

The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding);
Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment;
Pregnancy;
Expected fasting for ≥12 hours during the study period, for example, due to medical procedures;
Readmission in last 14 days;
Patients with burn injuries;
Participating in another nutritional intervention study.

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Interventions

OTHERIntermittent enteral nutrition

Participants will receive intermittent enteral nutrition in four separate portions between 8:00 a.m. and 8:00 p.m. Each portion will be administered over a one-hour period.