RecruitingNot ApplicableNCT07173530
Low Level Light Therapy & Skin Pigmentation
Sponsor
University of Houston
Enrollment
40 participants
Start Date
Jun 11, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.
Eligibility
Min Age: 18 Years
Inclusion Criteria3
- Ability to read and understand the study informed consent in English
- Age 18 years or older at enrollment
- Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.
Exclusion Criteria10
- Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis)
- History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome)
- History of corneal surgery, refractive surgery, or eyelid surgery within 6 months
- History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration)
- History of ocular trauma within 6 months
- History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months
- Habitual use of photosensitizing medications within the last 30 days
- Pregnant and/or lactating females, by self-report
- Pigmented lesions, tattoos, or skin cancer in the periocular region
- Unwilling to have eyes photographed or video recorded
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Interventions
DEVICEThree 15-minute low-level light therapy sessions using Light Emitting Diodes of wavelength 633nm (Essilor epi-c plus).
A mask with Light Emitting Diodes wavelength 633nm will be placed over closed eyes for 15 minutes.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07173530
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