Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
University Hospital Ostrava
492 participants
Feb 2, 2026
INTERVENTIONAL
Conditions
Summary
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.
Eligibility
Inclusion Criteria2
- Patients <18 years of age
- Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months
Exclusion Criteria7
- Patients who are unlikely to be weaned from ventilatory support.
- Patients in palliative care or with a survival probability of <3 months
- Patients with advanced malignancy
- Patients with a history of chronic kidney disease
- Patients with a history of chronic liver disease
- Patients with supranormal serum creatinine on admission to the post-ICU care unit
- Patients who refused to sign the Informed Consent with participation in the study.
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Interventions
Dietary supplement creatine. The dosage of creatine will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.
Dietary supplement polydextrose as a placebo. The dosage of placebo will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.
Patients in Group 1 will serve as controls and will receive no intervention, only standard care.
Locations(2)
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NCT07177183