RecruitingNCT07182903

Fatigue in MS: From Invisible to Measurable


Sponsor

University Medical Center Groningen

Enrollment

40 participants

Start Date

Oct 27, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Fatigue is one of the most common and burdensome symptoms of MS, but its precise cause remains unknown, and an effective treatment is lacking. Previous research has shown that the progression of MS is associated with a higher presence of a specific type of T-cell, the cytotoxic CD4+ T-cells, which play a role in the immune system. The aim of this study is to investigate whether these cells can also be linked to fatigue in people with MS.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating fatigue in people with multiple sclerosis (MS), aiming to find measurable biological and physical markers for this often invisible but debilitating symptom. It involves walking tests, foot-tapping tasks, and blood samples to track immune cell changes. **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with relapsing-remitting, primary progressive, or secondary progressive MS - You are able to perform a simple foot-tapping task - You are able to walk at least 20 meters (with or without a walking aid) **You may NOT be eligible if...** - You are taking dimethyl fumarate, fingolimod, or alemtuzumab (these heavily reduce the immune cells needed for the study) - You have had an MS relapse within the past 6 weeks - You have had an infection in the past month or a vaccination in the past 14 days - You are pregnant or planning to become pregnant - Your MS medication has changed in the past 6 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

UMCG

Groningen, Netherlands

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NCT07182903


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