RecruitingNot ApplicableNCT07187180

Evaluating the Clinical Efficacy of Thulio vs. Holmium Laser Enucleation of the Prostate


Sponsor

Smita De

Enrollment

50 participants

Start Date

Jun 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Many consider laser enucleation of the prostate the new 'gold standard' for the surgical treatment of benign prostatic hyperplasia (BPH) due to its excellent outcomes, high success rates, and long-term efficacy. Holmium laser enucleation of the prostate (HoLEP) was the earliest form of prostate enucleation and is recommended by the American Urological Association (AUA), along with thulium laser enucleation of the prostate (ThuLEP), as size-independent techniques for the management of BPH with fewer complications than transurethral resection of the prostate (TURP). Further development of laser technology has additionally led to enucleation using pulsed-modulated (e.g. "Virtual Basket™" mode or MOSES™ mode) holmium lasers as well as the thulium fiber laser.


Eligibility

Sex: MALEMin Age: 18 Years

Inclusion Criteria3

  • Understand and voluntarily sign an informed consent form.
  • Patients must be males with a prostate, at least 18 years of age
  • No prior prostate surgery

Exclusion Criteria4

  • Unable/refuse to provide informed consent
  • Prior prostate surgery
  • Bladder stones that requiring lasering (small stone that can be removed whole is ok)
  • Unable to hold anticoagulants or antiplatelets per standard protocols for surgery and up to 1 week postop.

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Interventions

DEVICEholmium laser

Prostate enucleation will holmium laser (control)

DEVICEpulsed thulium laser

experimental group - pulsed thulium laser prostate enucleation


Locations(1)

Cleveland Clinic Main

Cleveland, Ohio, United States

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NCT07187180


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